The beginning point of tiredness

These days I have been awfully tired....and even when my legs are aching like hell right now, i am wondering where does tiredness begin from....is it the limbs cos I move around / don't move around as much or the brain /thoughts that bring in the tiredness ?? like is exhaustion the decision of the mind or the body or a combination of the two or a strong link between the two that if the mind decides its tired, the signals are sent to the limbs or limbs just give up for the day, the brain tells me that i am tired and i need a break....!
My analysis --I didn't walk more than usual, run/skip/do other physical activity. I had a busy day at work where in I didn't realise the time fly ! So why are my legs aching ??
I am not sure if this is just my "tired state" talking, but this is what is on my mind right now!
Any points to make ?

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